Seminar Details

Seminar Details


Thursday

Dec 14

11:30 am

Bayesian Hierarchical Self-Modeling Warping Regression with Application to Network Inferences

Donatello Telesca

General Exam

University of Washington - Department of Statistics

Functional data often exhibit a common shape but also variations in amplitude and phase across curves. The analysis often proceed by synchronization of the data through curve registration. We propose a Bayesian Hierarchical model for curve registration. Our model provides a formal account of amplitude and phase variability while borrowing strength from the data across curves in the estimation of the model parameters. We discuss extensions of the model by utilizing penalized B-splines in the representation of the shape and time-transformation functions, and by allowing random image sets in the time transformation. We discuss applications of our model to simulated data as well as to two data sets. In particular, we illustrate using our model in a non-standard analysis aimed at investigating regulatory network in time course microarray data.