University of Washington - Department of Statistics
Current routine experimental methods for determining the genetic types of individuals in a population ("genotyping") typically do not provide haplotype information - i.e. information on which of the two alleles at each locus was inherited from the individual's mother, and which was inherited from the father. Nevertheless, haplotype information seems likely to play an important role in many future analyses of fine-scale molecular genetics data, particularly in the hunt for genes causing common diseases. Haplotypes can be obtained, at considerable cost, experimentally. Alternatively, a statistical method can be used. We will introduce this problem for a statistical audience, describe two existing statistical approaches, and compare them with a new improved method that exploits information on the patterns of haplotypes we expect to see in natural populations.