Details of course offerings have been removed from this page, due to changes. For planned course offerings over the period 2008-2013, please see the course offerings page.

A three course core sequence in statistical genetics is offered jointly by the departments of Statistics and Biostatistics. The sequence was first offered during the 1999-2000 academic year under the heading of special topics in advanced biostatistics. As of Fall 2000, the courses are established as BIOST/STAT 550-1-2.

STAT 550 Statistical Genetics I: Mendelian Traits (3) Thompson, Minin
Course web page (2012)
Mendelian genetic traits. Population genetics; Hardy-Weinberg, allelic variation, subdivision. Likelihood inference, information and power; latent variables and EM algorithm. Pedigree relationships and gene identity. Meiosis and recombination. Linkage detection. Multipoint linkage analysis. Prerequisite: STAT 390 and STAT 394, or permission of instructor. Offered: jointly with BIOST 550.

By the end of the course, the student should be able to:

BIOST 551 Statistical Genetics II: Quantitative Traits (3) Weir,Thornton
Course web page (2012)
Statistical basis for describing variation in quantitative traits. Decomposition of trait variation into components representing genes, environment and gene-environment interaction. Methods of mapping and characterizing quantitative trait loci. Prerequisite: STAT/BIOST 550; STAT 423 or BIOST 515; or permission of instructor. Offered: jointly with STAT 551.

By the end of the course, the student should be able to:

BIOST 552 Statistical Genetics III: Design and Analysis(3) Wijsman
Current web page (2012)
Use of discrete and quantitative genetic models for design and analysis for traits with a genetic basis. Different approaches to linkage analysis, finescale mapping, interpretation, real-life constraints, choosing among alternative designs, sample size estimation, and ascertainment. Prerequisites: STAT/BIOST 550, 551; or permission of instructor. Offered jointly with STAT 552.

By the end of the course, the student should be able to

 

In addition, the following classes are required:

GENOME 562 Population Genetics (4) Felsenstein
Current web page:2013
Mathematical and experimental approaches to the genetics of natural populations, especially as they relate to evolution. Emphasis on theoretical population genetics. Prerequisite: permission of instructor.

GENOME 540 Genome and Protein Sequence Analysis (4) Green
Current web page:2013
Algorithmic and probabilistic methods for analysis of DNA and protein analysis. Students must be able to write computer programs for data analysis. Prior coursework in biology and probability highly desirable. Prerequisite: permission of instructor.

as well as three consecutive quarters of participation in

Biostat 581 Seminar in Biostatistics: Statistical Genetics (max. 9) Wijsman, Weir, Thompson
Presentation and discussion of special topics and research results in statistical genetics.

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