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Please see %s for results and ALBERT.out for notes. @Genotype out of range in family %d. Trio excluded (Dad, Mom, Child): %d, %d, %d Parent(s) missing genotype data in family %d. Trio excluded (Dad, Mom, Child): %d, %d, %d More than one affected child in family %d. (Dad, Mom, Child used, Child not used): %d, %d, %d, %d ?Q?0@@Q??@@Y@{Gz?Hz>Could not allocate memory 1 in imatrix functionCould not allocate memory 2 in imatrix functionCould not allocate memory 1 in dmatrix functionCould not allocate memory 2 in dmatrix functionCould not allocate memory in dvector functionCould not allocate memory in ivector functionError opening pedigree file %s %d @@@?JanuaryFebruaryMarchAprilMayJuneJulyAugustSeptemberOctoberNovemberDecember )/59>CJT\e****************************************************** Please cite: Mitchell AA, Thompson EA ALBERT: A Likelihood-Based Estimation of Risk in Trios. Manuscript Submitted. Contact Adele Mitchell with bugs or questions: adele@u.washington.edu Date: %s %d, %d Time: %d : %.2d : %d Pedigree File: %s Marker TDTp allele p e r1 r2 LL nullP nullE nullLL LRT pvalue Marker TDTp allele p e1 e2 r1 r2 LL nullP nullE1 nullE2 nullLL LRT pvalue %d %.3lf %.4lf %.4lf %.3lf %.3lf %.2lf %.3lf %.4lf %.2lf %.3lf %.2e @ Interpretation of columns: TDTp: p-value obtained using TDT (Spielman et al., Am J Hum Genet 1993 52:506-16) allele: This is the allele associated with higher relative risks The next four columns represent MLEs when r1 and r2 are allowed to vary (i.e., alternative hypothesis) The next five columns represent MLEs when r1 and r2 are allowed to vary (i.e., alternative hypothesis) p: Population frequency of allele in previous column Simple Error Model: e: Probability one allele miscalled as other Allelic Dropout Model: e1: Probability homozygote miscalled as heterozygote, e2: vice versa r1: Genotype relative risk associated with carrying 1 copy of allele listed vs. no copies r2: Genotype relative risk associated with carrying 2 copies of allele listed vs. no copies LL: -1 times Log likelihood of data using alternative hypothesis MLEs The next two columns represent MLEs when r1 and r2 are fixed at 1.0 (i.e., null hypothesis) The next three columns represent MLEs when r1 and r2 are fixed at 1.0 (i.e., null hypothesis) nullLL: -1 times Log likelihood of data using null hypothesis MLEs LRT: 2 times (LL minus nullLL) pvalue: ALBERT pvalue. LRT using chi square distribution with 2 degrees of freedom. Note: p value not adjusted for multiple testing. Invalid arguments in routine gammqx less than 0 in routine gsera too large, ITMAX too small in routine gserv !>a too large, ITMAX too small in function gcf@KH9v !>@?' @Numerical Recipes run-time error... %s Now exiting... 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