STAT/BIOSTAT 550:
Statistical Genetics I; Discrete Mendelian traits
Distance Learning Version: Spring 2010

Instructor: Elizabeth Thompson

Some preliminary information

Note that many links within these documents are not yet working

  • The schedule: updating as we go
  • Course materials (other than the lectures)

    Access restricted to registered students and other specific personnel.

    Lecture presentations

    The primary web-based material will be through audio and visual presentations: these will be made accessible to registered students only.
    Chapter 1 part 1 . 1.1, 1.2: Introduction Handouts (PDF)

    Chapter 1 part 2 . 1.3 Estimation of allele frequencies. Handouts (PDF)

    Chapter 1 part 3 . 1.4, 1.5 Testing HWE and other hypotheses. EM algorithm. Handouts (PDF)

    Chapter 1 part 4 . 1.6, 1.7 Haplotyping. Mutation, selection and random genetic drift. Handouts (PDF)

    Chapter 2 part 1 . 2.1, 2.2 Pedigrees, gene identity by descent, Kinship and inbreeding. Handouts (PDF)

    Chapter 2 part 2 . 2.3, 2.4 IBD in genes of related individuals. Genotypic data on relatives. Handouts (PDF)
    This is a long audio!! more than one hour. Do not try to absorb it all at once.
    For Chapter 3, things are split into smaller pieces.

    Chapter 3 part 1 . 3.1 Haplotypes and allelic association. Handouts (PDF)

    Chapter 3 part 2 . 3.2 Counting recombinants and estimating recombination Handouts (PDF)

    Chapter 3 part 3 . 3.3,3.4 Power and information in linkage analysis Handouts (PDF)

    Chapter 3 part 4 . 3.5,3.6 Two locus ibd and homozygosity mapping Handouts (PDF)

    Chapter 4 part 1 . 4.1 Meiosis, Genetic maps, and multilocus recombination Handouts (PDF)

    Chapter 4 part 2 . 4.2 Multilocus inheritance and HMM methods for small pedigrees Handouts (PDF)

    Chapter 4 part 3 . 4.3 Big pedigrees, and an introduction to Monte Carlo methods Handouts (PDF)


    UW - Statistics: Friday, 21-May-10 Contact: Elizabeth Thompson <eathomp@u.washington.edu>