Biostat 580B - Statistical Genetics Seminar
Winter Quarter 2005
Seminar: Tuesday 4:00-5:00, in T635 HSB
(watch THIS space for any room change)
WINTER 2005 SCHEDULE
We will fix the topics, speakers, and specific papers --
our focus will be trait models in linkage analyses in natural and experimantal
Please come prepared!
Jan 11: Ellen Wijsman
Ellen will introduce some of the issues in the area of trait
modelling, by talking about their work in late-onset Alzheimer disease.
The Number of Trait Loci in Late-Onset Alzheimer Disease.
E. Warwick Daw, Haydeh Payami, Ellen J. Nemens, David Nochlin,
Thomas D. Bird, Gerard D. Schellenberg, and Ellen M. Wijsman.
American Journal of Human Genetics, 66: 196--204. (January 2000)
Evidence for a Novel Late-Onset Alzheimer Disease Locus on Chromosome 19p13.2.
Ellen M. Wijsman, E. Warwick Daw, Change-En Yu, Haydeh Payami, Ellen J. Steinbart, David Nochlin, Erin M. Conlon, Thomas D. Bird, and Gerard D.
Schellenberg Wijsman et al.
American Journal of Human Genetics, 75: 398--409. (July 2004)
Jan 18: Audrey Fu and Liping Tong
Jan 25: Garrett Hellenthal and Yoonha Choi
The topic is censored data/phenotypes. The paper is:
Feb 1: Haoyuan Zhu and I-Yu Chiu
The topic is penetrance, in context of complex traits.
We have both a general paper, and an example from a few pages of a
more complex example:
Feb 8: Grace Ge and Paul Scheet
The topic is models for longitudinal data. The first paper
following is the
methodology paper underlying two of the longitudinal data analyses
of the Framingham data in GAW13
(by some of the same authors): these GAW13 refs are also given FYI.
- Scurrah, K.J., Palmer, L.J., Burton P.R. 2000
Variance components analysis
for pedigree-based censored survival data using generalized linear mixed
models (GLMMs) and Gibbs sampling in BUGS. Genet Epidemiol, 19:127-148.
Scurrah, K. J., Tobin, M. D., Burton, P. R. 2003
components models for systolic blood pressure, fitted using Gibbs sampling.
BMC Genetics 4(Suppl 1):S25.
Palmer, L.J., Scurrah, K.J., Tobin, M., Patel, S.R., Celedon, J.C., Burton,
P.R., Weiss, S.T. 2003
Genome-wide linkage analysis of longitudinal
phenotypes using s2A random effects (SSARs) fitted by Gibbs sampling.
BMC Genetics 4(Suppl 1): S12
Feb 15: Joe Rothstein and Julian Wolfson
Topic: Major gene covariates:
Add codes for next quarter: please contact Katie Kerr (katiek@u)--
soon, not quite yet, I think!
Feb 22: Arindam RoyChoudhury and Saonli Basu
Additionally, Arindam has place a few pages from the following book in
the Stat and Biostat StatGen Seminar boxes/folders:
Topic: Missing phenotypes and covariates.
Here is one brief overview paper:
- Roderick J.A. Little, Donald B. Rubin (2002)
Statistical analysis with missing data
Wiley, New York.
Mar 1: Rob Igo : research talk.
Analysis of a Complex Trait: The Case of the Disappearing Model.
Mar 8: Angel Wan : research talk.
Power, Type I error, parameter estimation of the variance
components method in Bivariate linkage analysis of quantitative traits
using samples of random families