ALBERT: A Likelihood-Based Estimation of Risk in Trios
ALBERT is a C program that estimates genotype relative risks, genotyping
error rates and population risk allele
frequencies from marker genotype data in case-parent trios. ALBERT uses the
distribution of trio marker
genotypes to compute maximum likelihood estimates for the parameters.
Complete instructions for running the
program can be found in the documentation "albert.pdf" which can be
downloaded here. Briefly, ALBERT runs on
unix and requires two files, a marker file and a pedigree file (in LINKAGE
format). The user must specify the
names of these files on the command line, as well as the name of an output
file that ALBERT will create.
Finally, the user must specify one of the two available error models which
are described in the documentation.
Do not remove Mendelian inconsistencies from your data before
running ALBERT! The program makes use of
visible genotyping errors in its parameter estimates.
Until ALBERT is published, only the executable file will be available.
Following publication, the source code
will also be available. If you use ALBERT, please cite
Mitchell AA and Thompson EA.
ALBERT: A Likelihood-Based Estimation of Risk in Trios. Submitted
Email questions or bugs to Adele Mitchell at firstname.lastname@example.org
May 17, 2006
Download executable and documentation here
| Name || Description ||Size
Executable file (Compiled for Linux on Dell PC)
PDF file of documentation