Biostat 580B - Statistical Genetics Seminar
Winter Quarter 2004
Seminar: Tuesday 3:45-4:45, in F643 HSB
This is a participatory seminar! Students, postdocs, faculty
all present their own work and/or papers from the literature.
Remember the important questions:
Why? What? Why? How? Why? What next? and WHY?
(Why is this question important? What did they do? Why did they choose this
How did they do it? Why did they choose these methods? What should
come next? Why is this the next logical step?)
Reminder: Everyone should read the papers for weeks in which
we read a journal article.
If the paper is available electronically, we will provide the reference, and
you may download your own copy from
healthlinks web site,
or through the
UW e-journals page.
If the paper is not available electronically,
the discussion leaders should make 2 copies, and should put one copy in each of
stat mailbox and the biostat 580B homework folder,
preferably a week ahead of time.
The stat mailbox is in the mail room in statistics;
the biostat 580B homework folder is
in the top left drawer underneath the biostat mailboxes
in a folder to the far left
as you face the mailboxes.
Others should then make their copies from one of these two copies.
Discussion leaders are only expected to spend 20-30 minutes (jointly)
presenting the assigned paper(s). If you don't understand everything, focus on
what you can, and try to think about what is important about the papers, and
what open questions you are left with. KEEP THE NUMBER OF PREPARED
TRANSPARENCIES TO A SMALL NUMBER (AROUND 6), TO ENCOURAGE DISCUSSION.
MAKE SURE YOU LEAVE ADEQUATE TIME FOR
Statistical Genetics Computing in Biostat
Statistical Genetics at UW has
software installed for the use of UW StatGen students and others.
This software is installed and maintained at
our Statgen Biostatistics computing page. To use the software,
a biostat computing account is needed:
Biostat 580B seminar participants may obtain an account through this class.
(Since this is an ongoing class, with ongoing participation by StatGen people
(we hope!), we believe this will lead to less admin headaches for all.)
Please note: Your Biostat computing account given
in connection with
the Statistical Genetics seminar is for learning and exploring the software,
for doing your research computing. Your research computing should be done
on computing resources allocated for that purpose.
For lists of previously
suggested topics, click
WINTER 2004 SCHEDULE
Jan 6: CANCELLED BY UW DUE TO SNOW
Please email firstname.lastname@example.org asap if you still need an
entry code, or if you have one, but forgot it, and have not yet registered.
Jan 13: Lixuan Qin
- Lixuan will talk about her work with Katie Kerr on microarray experiments.
Two suggested overview papers are:
prepared to asked all your questions about microarrays -- Lixuan fears
the seminar may be too short, but, if it is, it is the other participants'
fault, not hers.
- Statistical tests for differential expression in cDNA microarray
experiments", Cui and Churchill
- Statistical methods for identifying differentially expressed genes in
replicated cDNA microarray experiments, Dudoit, Yang, Callow, and Speed
- Everyone should please also bring a topic that
they want to learn something about (relevant to statistical genetics).
written down on a piece of paper -- Ellen has volunteered to collect the
bits of paper, and Bill and Paul have each volunteered to get them to
my mail box.
For previous lists of topics, see links on this web page.
Jan 20: Paul Scheet
COMBI seminar (1.30 p.m.) Elizabeth Thompson )
Jan 27: Elisabeth Rosenthal, Terri Kim
- Kaplan, N; Morris, R
Prospects for association-based fine mapping of a susceptibility
gene for a complex disease
THEORETICAL POPULATION BIOLOGY, 60 (3): 181-191 NOV 2001
Feb 3: Garrett Hellenthal, Ying Huang
Garrett and Ying will focus on the McVean theory paper. The other paper
is the data paper that motivated this line of research, but we will
probably not get into the data paper this week.
- Gilean A. T. McVean (2002)
A genealogical interpretation of linkage disequilibrium
Genetics 162, 987-991
D E Reich, S F Schaffner, M J Daly, G McVean, J C Mullikin, J M Higgins,
D J Richter, E S Lander and D Altshuler
Human genome sequence variation and the influence of gene history, mutation and
Nature Genetics 32: 135-142
Feb 10: Rob Igo, with Mike Badzioch (et al?)
- Loki: Star Performer or Supporting Player?: Comparing Methods for
Linkage Analysis on Complex Quantitative Traits
Feb 17: Caroline Cutting, Ting-Yuan Liu
Feb 24: Arindam RoyChoudhury, Joe Rothstein
- Pritchard and Cox (2002)
The allelic architecture of human disease genes:
common disease --common variant ... or not?
Human Molecular Genetics 11: 2417--2423.
Mar 2: Audrey Fu, Saonli Basu
- Slatkin M. and Bertorelle G. (2002?)
The use of intraallelic variability for testing neutrality and estimating
population growth rate.
Genetics 158: 865--874.
Mar 9: Professor Bruce Weir, NCSU
Mar 12 and Mar 17:
For those interested: Bill Stewart
will give his exam preview talk in Mathgen,
C301 PDL, 1.30 p.m. Fri, Mar 12:
better yet, come to his General Exam,
SAV 245, 9.00 a.m. Wed March 17!
For a link to other seminars of related interest,
For a link to previous schedules of the statistical genetics
seminar, click here.
Tuesday, 09-Mar-2004 20:58:13 PST
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